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Allele : Tc(HSA17*N279K)1Mdk transchromosomal, human 17, line 1, Michael Koob; transchromosomal, human 17, line 1, Michael D Koob
Primary Identifier  MGI:6705043 Allele Type  Targeted
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Tc(HSA17*N279K)1Mdk
Transmission  Germline Strain of Origin  C57BL/6NTac
Is Recombinase  false Is Wild Type  false
molecularNote  A 157 kb deletion on mouse chromosome 11 stretching from, but not including, Crhr1 to Kansl1 is replaced by a syntenic 190 kb region from human chromosome 17 (HSA17). The mouse Sppl2c (signal peptide peptidase 2C) and Mapt (microtubule-associated protein tau) genes are replaced by human SPPL2C and MAPT (H1 haplotype) genes. The human MAPT gene was modified to include the N279K (asparaginine to lysine) mutation identified in FTD patients. A loxN-flanked neomycin resistance cassette that was removed by transient cre expression.
  • mutations:
  • Nucleotide substitutions,
  • Intergenic deletion,
  • Insertion
  • synonyms:
  • MAPT(H1.0*N279K)-GR,
  • MAPT(H1.0*N279K)-GR
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1 Feature

Genome

4 Expresses

6 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

4 Publication categories





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