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Allele : Rock1<tm1.1Bicrq> Rho-associated coiled-coil containing protein kinase 1; targeted mutation 1.1, Cancer Research UK Beatson Institute
Primary Identifier  MGI:6696418 Allele Type  Targeted
Gene  Rock1 Transmission  Germline
Strain of Origin  (129S6/SvEvTac x C57BL/6NCrl)F1 Is Recombinase  false
Is Wild Type  false
molecularNote  Exon 27 was replaced with a floxed neomycin resistance cassette and a modified exon 27 with the amino acid substitution of aspartic acid with alanine at position 1113 (D1113A) to make the produced protein caspase-resistant. Cre-mediated recombination removed the selection cassette.
  • mutations:
  • Insertion,
  • Nucleotide substitutions
  • synonyms:
  • ROCK1nc,
  • ROCK1 D1113A,
  • ROCK1nc,
  • ROCK1 D1113A
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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5 Publication categories

Trail: Allele




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