| Primary Identifier | MGI:6729893 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Atp1a2 |
| Transmission | Germline | Strain of Origin | Not Specified |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A T to C transition at position 2763 (position 2659 on Build GRCm39) resulting in a tryptophan to arginine substitution at amino acid 887 was inserted into exon 19. An FRT-flanked neomycin selection cassette was inserted downstream of exon 19 and removed via Flp-mediated recombination. This is a mutation associated with human familial hemiplegic migraine type 2. The mutant protein is barely detectable in the brain of homozygotes and reduced in heterozygotes. |
