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Allele : Dock8<tm1.1Geno> dedicator of cytokinesis 8; targeted mutation 1.1, Genoway

Primary Identifier	MGI:6716854	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Dock8
Transmission	Germline	Strain of Origin	Not Specified
Is Recombinase	false	Is Wild Type	false

molecularNote

A loxP site was inserted into intron 8 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 10. Floxed exons 9 and 10 were deleted through subsequent cre-mediated recombination.

mutations:
Insertion,
Intragenic deletion

cellLines:
Not Specified

synonyms:
Dock8<->,
Dock8<->

earliestPublication:
Schneider C, et al. (2020) Migration-induced cell shattering due to DOCK8 deficiency causes a type 2-biased helper T cell response. Nat Immunol 21(12):1528-1539

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

3 Publication categories

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