| First Author | Chen L | Year | 2019 |
| Journal | FASEB J | Volume | 33 |
| Issue | 7 | Pages | 7942-7952 |
| PubMed ID | 30922124 | Mgi Jnum | J:290215 |
| Mgi Id | MGI:6442018 | Doi | 10.1096/fj.201802704R |
| Citation | Chen L, et al. (2019) Estrogen-related receptor gamma regulates hepatic triglyceride metabolism through phospholipase A2 G12B. FASEB J 33(7):7942-7952 |
| abstractText | Hypersecretion of hepatic very LDL (VLDL)-associated triglyceride (TG) is the hallmark of hypertriglyceridemia. The estrogen-related receptor gamma (ERRgamma), an orphan nuclear receptor, plays crucial roles in the regulation of metabolic homeostasis, including TG formation in the liver. It remains unclear whether ERRgamma regulates hepatic VLDL-TG secretion. We demonstrated that knockdown of ERRgamma impairs hepatic VLDL-TG secretion in mice, whereas overexpression of ERRgamma favors the secretion, indicating a novel role of ERRgamma in hepatic TG metabolism. We found that ERRgamma transcriptionally regulates the expression of PLA2G12B by binding to the promoter region of the Pla2g12b gene. In Pla2g12b-null mice, ERRgamma fails to regulate hepatic VLDL-TG secretion. There is an apparent accumulation of large lipid droplets in the liver of Pla2g12b-null mice. These data suggest that ERRgamma is a novel regulator of hepatic VLDL-TG secretion, which is mediated through the action on PLA2G12B.-Chen, L., Wu, M., Zhang, S., Tan, W., Guan, M., Feng, L., Chen, C., Tao, J., Chen, L., Qu, L. Estrogen-related receptor gamma regulates hepatic triglyceride metabolism through phospholipase A2 G12B. |
