Primary Identifier | MGI:6835669 | Allele Type | Targeted |
Attribute String | Conditional ready, No functional change | Gene | Tnfsf10 |
Transmission | Germline | Strain of Origin | C57BL/6N-A<tm1Brd> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The targeting construct inserted a loxP site upstream of exon 2 and an FRT site, loxP site, 2A sequence, and a truncated (nonfunctional) NGFR reporter gene for cre-mediated deletion downstream of exon 5. FLP-mediated recombination removed the selection cassette inserted downstream of exon 5. NGFR expression is minimal even upon cre-mediated recombination thus cannot be used as intended. |