| Primary Identifier | MGI:6718305 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Trp53 |
| Transmission | Germline | Strain of Origin | 129X1/SvJ |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A G-to-C mutation resulting in an arginine to histidine substitution at amino acid 334 (p.R334H) was introduced in exon 10 and a loxP-flanked cassette containing neomycin resistance and thymidine kinase genes was inserted into intron 9. Cre-mediated recombination removed the selection cassette. This is a mutation associated with variable tumor susceptibility in humans. |
