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Allele : Igh<tm2.1(Myc)Janz> immunoglobulin heavy chain complex; targeted mutation 2.1, Siegfried Janz
Primary Identifier  MGI:6741072 Allele Type  Targeted
Attribute String  Epitope tag, Inserted expressed sequence Gene  Igh
Transmission  Germline Strain of Origin  Not Specified
Is Recombinase  false Is Wild Type  false
molecularNote  Heavy-chain enhancer Emu, downstream of the J gene segment, was replaced with a construct consisting of a 1.5 kb segment of genomic 5' flanking sequence from the mouse Myc gene with the P1/P2 promoters, the first noncoding exon, a mouse Myc intron-less cDNA clone with an in-frame 6x histidine tag sequence on the 3' end, a short segment of the 3' UTR including the major polyadenylation signal, and a loxP site flanked neomycin resistance gene cassette, all in opposite transcriptional orientation compared to the host gene. The neo cassette was removed through subsequent cre-mediated recombination.
  • mutations:
  • Insertion,
  • Intergenic deletion
  • synonyms:
  • c-myc-KICmu,
  • iMyc<deltaEmu>,
  • iMyc<deltaEmu>,
  • c-myc-KICmu
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

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0 Driven By

7 Publication categories

Trail: Allele




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