Primary Identifier | MGI:7710877 | Allele Type | Targeted |
Attribute String | Null/knockout, Reporter | Gene | Dusp26 |
Transmission | Germline | Strain of Origin | 129S2/SvPas |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The targeting vector was designed to insert a beta-galactosidase gene (lacZ) immediately downstream of the ATG start codon (exon 3) of the dual specificity phosphatase 26 (Dusp26) gene via homologous recombination in ES cells. The construct also contained a loxP-flanked neomycin cassette following the LacZ sequence. The insertion results in the ablation of endogenous Dusp26 expression. |