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Allele : Il6<em3Smoc> interleukin 6; endonuclease-mediated mutation 1, Shanghai Model Organisms Center

Primary Identifier	MGI:6763033	Allele Type	Endonuclease-mediated
Attribute String	Null/knockout, Reporter	Gene	Il6
Strain of Origin	C57BL/6JSmoc	Is Recombinase	false
Is Wild Type	false

molecularNote

A luciferase-2A-EGFP-pA cassette was inserted after the ATG start codon. The intrinsic promoter drives the expression of the reporter genes reflecting the activity of Il6.

mutations:
Insertion

synonyms:
IL-6<->,
Il6<em1(Luc-eGFP)Smoc>,
IL-6<->,
Il6<em1(Luc-eGFP)Smoc>

earliestPublication:
Chen X, et al. (2020) Interleukin-6 promotes proliferative vitreoretinopathy by inducing epithelial-mesenchymal transition via the JAK1/STAT3 signaling pathway. Mol Vis 26:517-529

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

2 Publication categories

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