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Allele : Prkdc<em5Lutzy> protein kinase, DNA activated, catalytic polypeptide; endonuclease-mediated mutation 5, Cathy Lutz
Primary Identifier  MGI:6763019 Allele Type  Endonuclease-mediated
Attribute String  Null/knockout Gene  Prkdc
Strain of Origin  NOD/ShiLtJ Is Recombinase  false
Is Wild Type  false
molecularNote  CRISPR/cas9 genome editing is used to create a 390-nt deletion that resulted in the complete loss of exon 5 (as well as 119bp upstream and 162bp downstream). This is designed to create a knock-out allele resulting in a premature stop codon at amino acid 135. Prkdc transcript Prkdc-201 was used as reference for the exon number and the guide sequences.
  • mutations:
  • Intragenic deletion
  • synonyms:
  • Prkdc del390,
  • Prkdc del390
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Trail: Allele

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0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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