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Allele : Tg(MMTV-CCND1*K112E)#Rgp transgene insertion, Richard G Pestell

Primary Identifier  MGI:6758519 Allele Type  Transgenic
Attribute String  Epitope tag, Humanized sequence, Inserted expressed sequence Gene  Tg(MMTV-CCND1*K112E)#Rgp
Is Recombinase  false Is Wild Type  false
molecularNote  A mutated form of the human cyclin D1 cDNA, preceded by sequence for a N-terminal 2xFLAG tag and followed by SV40 poly(A) signal sequences, was placed downstream of the mouse mammary tumor virus promoter. The mutation is a G-to-A mutation that changes lysine codon 112 to a glutamic acid codon (p.K112E), eliminating or severely reducing the protein's phosphorylation (kinase) activity.
  • mutations:
  • Insertion
  • synonyms:
  • MMTV-CCND1<KE>,
  • MMTV-CCND1<KE>
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1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

2 Publication categories