| Primary Identifier | MGI:6784048 | Allele Type | Transgenic |
| Attribute String | Epitope tag, Humanized sequence, Inserted expressed sequence | Gene | Tg(Prnp-UBQLN2*P506T)#Hlp |
| Strain of Origin | (C57BL/6 x SJL)F2 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The transgene contains the following elements: the mouse prion protein gene promoter and exon 1, intron 1 and exon 2, sequence coding for a FLAG tag in-frame with the human Ubqln2 cDNA that has been modified to change proline codon 506 into a threonine codon (p.P506T), and Prnp exon 3 and downstream sequence. The mutation is associated with familial frontotemporal dementia/amyotrophic lateral sclerosis (FTD/ALS). |
