| Primary Identifier | MGI:6759435 | Allele Type | Endonuclease-mediated |
| Attribute String | Humanized sequence | Gene | Clp1 |
| Strain of Origin | C57BL/6J | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | CRISPR/cas9 genome editing is used to introduce a G to A mutation (gRNA c.403-422; donor oligo c357-486 with c.419G to A and c.426C to A; NM_133840.2) at position 419 resulting in an arginine to histidine missense mutation (R140H) in the first coding exon (exon 2). The mutation homologous to one found in pontocerebellar hypoplasia type 10 (PCH10) patients. |
