| First Author | Sassa T | Year | 2023 |
| Journal | Cell Rep | Pages | 112363 |
| PubMed ID | 37054712 | Mgi Jnum | J:335285 |
| Mgi Id | MGI:7468522 | Doi | 10.1016/j.celrep.2023.112363 |
| Citation | Sassa T, et al. (2023) Involvement of omega-O-acylceramides and protein-bound ceramides in oral permeability barrier formation. Cell Rep :112363 |
| abstractText | The permeability barrier present in the oral cavity is critical for protection from infection. Although lipids have properties suitable for permeability barrier formation, little is known about their role in oral barrier formation. Here, we show the presence of omega-O-acylceramides (acylceramides) and protein-bound ceramides, which are essential for the formation of permeability barriers in the epidermis, in the oral mucosae (buccal and tongue mucosae), esophagus, and stomach in mice. Conditional knockout of the fatty acid elongase Elovl1, which is involved in the synthesis of >/=C24 ceramides including acylceramides and protein-bound ceramides, in the oral mucosae and esophagus causes increased pigment penetration into the mucosal epithelium of the tongue and enhanced aversive responses to capsaicin-containing water. We find acylceramides in the buccal and gingival mucosae and protein-bound ceramides in the gingival mucosa in humans. These results indicate that acylceramides and protein-bound ceramides are important for oral permeability barrier formation. |
