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Allele : Map3k13<em1Yjin> mitogen-activated protein kinase kinase kinase 13; endonuclease-mediated mutation 1, Yishin Jin

Primary Identifier	MGI:6840986	Allele Type	Endonuclease-mediated
Attribute String	Null/knockout	Gene	Map3k13
Strain of Origin	C57BL/6	Is Recombinase	false
Is Wild Type	false

molecularNote

Using CRISPR-Cas9 technology, sgRNA sequences targeted to the kinase domain of the Map3k13 gene were designed. Two KO mouse lines were obtained and the one containing a deletion of the entire kinase domain was used in this study.

mutations:
Intragenic deletion

synonyms:
Map3k13<KO>,
Map3k13<KO>

earliestPublication:
Li Y, et al. (2021) Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength. Elife 10:e63509

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

2 Publication categories

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