| Primary Identifier | MGI:6781957 | Allele Type | Targeted |
| Gene | F2r | Transmission | Germline |
| Strain of Origin | C57BL/6NTac | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | A mutation was engineered in exon 2 to change arginine codon 46 (AGG) to a glutamine codon (CAG)(p.R46Q) and an FRT site flanked neomycin resistance gene cassette was inserted into intron 1. The neo cassette was removed through subsequent flp-mediated recombination. The mutation prevents cleavage at that residue by activated protein C (APC). |
