| Primary Identifier | MGI:6782402 | Allele Type | Targeted |
| Gene | Ryr2 | Transmission | Germline |
| Strain of Origin | C57BL/6 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | A mutation was engineered in exon 76 to change valine codon 3598 to a lysine codon (p.V3598K) and a loxP site flanked neomycin resistance gene cassette was inserted into intron 76. The neo cassette was removed through subsequent cre-mediated recombination. The mutation in the calmodulin (CaM) binding domain significantly increases binding affinity of the encoded peptide to calmodulin. |
