| Primary Identifier | MGI:6854706 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Nrg1 |
| Transmission | Germline | Strain of Origin | 129 |
| Is Recombinase | false | Is Wild Type | false |
| description | The version of this allele that contains the neomycin selection cassette, Nrg1tm1Lrw, has been analyzed. |
| molecularNote | The cysteine-rich domain (CRD) in the alternatively spliced N-terminus was disrupted by the creation of a nonsense mutation and an Xba1 site in the exon encoding the CRD. A loxP site flanked neomycin resistance gene cassette was inserted into the intron following the CRD-encoding exon. Germline, cre-mediated recombination removed the loxP-flanked neomycin cassette. |
