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Allele : Gt(ROSA)26Sor<em1(CAG-ACE2)Mlkn> gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Mark L Kahn
Primary Identifier  MGI:6842323 Allele Type  Endonuclease-mediated
Attribute String  Conditional ready, Humanized sequence, Inserted expressed sequence Gene  Gt(ROSA)26Sor
Transmission  Germline Strain of Origin  (C57BL/6 x 129S4/SvJae)F1
Is Recombinase  false Is Wild Type  false
molecularNote  CRISPR/cas9 mediated recombination inserted a CAG promoter, floxed stop cassette, modified human ACE2 cDNA, woodchuck hepatitis virus post-transcriptional regulatory element, simian virus 40 polyA sequence, loxP site, and an FRT-flanked PGK-neo cassette. The human ACE2 cDNA was modified to use the mouse Ace2 signal peptide and codon optimized for mouse.
  • mutations:
  • Insertion
  • synonyms:
  • LSL-hACE2,
  • LSL-hACE2
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1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

5 Publication categories





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