| Primary Identifier | MGI:6782864 | Allele Type | Endonuclease-mediated |
| Attribute String | Not Specified | Gene | L1cam |
| Strain of Origin | C57BL/6J x CBA | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Zinc finger nuclease mediated recombination converted the sequence AGAAAGCACAGCAAGAGG (position 73,857,812-73,857,795) to AGCAAGCACAGCTCGAGC changing the amino acid sequence at positions 858-863 from RKHSKR to SKHSSS. This mutation disrupts the MBP cleavage site preventing the production of the L1-70 and L1-80 fragments. However, the full length protein is expressed. |
