Primary Identifier | MGI:6856810 | Allele Type | Endonuclease-mediated |
Attribute String | Modified regulatory region | Gene | H19 |
Strain of Origin | C57BL/6J | Is Recombinase | false |
Is Wild Type | false |
molecularNote | Inversion of the H19 ICR sequence was induced at the mouse endogenous locus by CRISPR/Cas9 genome editing. Three lines carried correctly inverted ICR alleles; two of those three carried the artificial enzyme site. This is a mutant mouse line 23 established from these two F0 mice (lines 21 and 23). |