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Allele : Mrps12<em2.2Afi> mitochondrial ribosomal protein S12; endonuclease-mediated mutation 2.2, Aleksandra Filipovska

Primary Identifier  MGI:6842913 Allele Type  Endonuclease-mediated
Gene  Mrps12 Strain of Origin  C57BL/6N
Is Recombinase  false Is Wild Type  false
molecularNote  CRISPR-targeting floxed the endogenous exon 2 and inserted an exon 2 with a point mutations encoding the amino acid substitution lysine to threonine at position 71 (K71T). This mutation produces a protein with hyper-accurate translation (ha). Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. Cre-mediated recombination removed the endogenous exon 2.
  • mutations:
  • Single point mutation,
  • Insertion
  • synonyms:
  • Mrps12<ha>,
  • Mrps12<ha>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

4 Publication categories