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Allele : Cacna1s<tm1.1Slh> calcium channel, voltage-dependent, L type, alpha 1S subunit; targeted mutation 1.1, Susan L Hamilton
Primary Identifier  MGI:6887473 Allele Type  Targeted
Attribute String  Not Specified Gene  Cacna1s
Transmission  Germline Strain of Origin  129S7/SvEvBrd-Hprt1<b-m2>
Is Recombinase  false Is Wild Type  false
molecularNote  Glutamic acid codon 1014 (GAG) in exon 24 was changed to a lysine codon (AAG)(p.E1014K). The loxP site flanked neomycin resistance gene cassette that was inserted into intron 23 was removed through subsequent cre-mediated recombination. The mutation affects the Ca2+ permeability of the Ca2+ channel formed by Cacna1s.
  • mutations:
  • Single point mutation
  • synonyms:
  • EK,
  • CaV1.1 E1014K,
  • EK,
  • CaV1.1 E1014K
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

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0 Driven By

4 Publication categories





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