| First Author | Sun Y | Year | 2014 |
| Journal | J Immunol | Volume | 193 |
| Issue | 2 | Pages | 860-70 |
| PubMed ID | 24935926 | Mgi Jnum | J:320371 |
| Mgi Id | MGI:6851935 | Doi | 10.4049/jimmunol.1400045 |
| Citation | Sun Y, et al. (2014) PILRalpha negatively regulates mouse inflammatory arthritis. J Immunol 193(2):860-70 |
| abstractText | Paired Ig-like type 2 receptor (PILR)alpha inhibitory receptor and its counterpart PILRbeta activating receptor are coexpressed on myeloid cells. In this article, we report that PILRalpha, but not PILRbeta, is elevated in human rheumatoid arthritis synovial tissue and correlates with inflammatory cell infiltration. Pilralpha(-/-) mice produce more pathogenic cytokines during inflammation and are prone to enhanced autoimmune arthritis. Correspondingly, engaging PILRalpha with anti-PILRalpha mAb ameliorates inflammation in mouse arthritis models and suppresses the production of proinflammatory cytokines. Our studies suggest that PILRalpha mediates an important inhibitory pathway that can dampen inflammatory responses. |
