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Allele : Rragc<em1Efe> Ras-related GTP binding C; endonuclease-mediated mutation 1, Alejo Efeyan

Primary Identifier	MGI:6874615	Allele Type	Endonuclease-mediated
Attribute String	Hypomorph	Gene	Rragc
Strain of Origin	Not Specified	Is Recombinase	false
Is Wild Type	false

molecularNote

CRISPR-cas9 mediated recombination using a guide RNA (reverse orientation TCAAAGAAGTCCATCTGCCCAGG) introduced a CAG to CTC mutation, resulting in a Q119L mutation.

mutations:
Nucleotide substitutions

synonyms:
RagC<Q119L>,
RagC<Q119L>

earliestPublication:
Ortega-Molina A, et al. (2021) Inhibition of Rag GTPase signaling in mice suppresses B cell responses and lymphomagenesis with minimal detrimental trade-offs. Cell Rep 36(2):109372

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

3 Publication categories

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