| Primary Identifier | MGI:7414300 | Allele Type | Endonuclease-mediated |
| Gene | Ubap1 | Strain of Origin | (C57BL/6 x DBA/2)F1 x C57BL/6N |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | CRISPR/Cas9 technology generated an alanine duplication at position 527 (c.527dupA) resulting in a frameshift that leads to a termination codon 23 residues after the glutamate at amino acid 176 (p.E176Efx23). This results in the complete deletion of the C-terminal solenoid of overlapping ubiquitin-associated (SOUBA) domain and the loss of ubiquitin binding. Mutant transcript was detected in heterozygous brain. |
