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Allele : Mlh3<em1Jcs> mutL homolog 3; endonuclease-mediated mutation 1, John C Schimenti
Primary Identifier  MGI:7276200 Allele Type  Endonuclease-mediated
Attribute String  Humanized sequence Gene  Mlh3
Strain of Origin  FVB/NJ x B6(Cg)-Tyr<c-2J>/J Is Recombinase  false
Is Wild Type  false
molecularNote  Using an sgRNA (targeting GCAAGTATAGCCGACATGGC) and an ssODN template (AGCATTTTATGGCTTCGGAGGAGAGGCCTTGGCAAGTATAGCCGACATGGCTGGTGCTGTGGAGATTTCATCCAAGAAAAACACAACACTGAAAA) with CRISPR/Cas9 technology, arginine codon 93 (CGA) was changed to glycine (GGA) (c.277C>G, p.R93G).
  • mutations:
  • Single point mutation
  • synonyms:
  • Mlh3<R93G>,
  • Mlh3<R93G>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

2 Publication categories





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