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Allele : Cdh2<em1Obir> cadherin 2; endonuclease-mediated mutation 1, Ohad S Birk

Primary Identifier	MGI:7432734	Allele Type	Endonuclease-mediated
Attribute String	Humanized sequence	Gene	Cdh2
Strain of Origin	C57BL/6JRcc	Is Recombinase	false
Is Wild Type	false

molecularNote

CRISPR/Cas9 technology generated a histidine to tyrosine substitution at amino acid 150. This corresponds to the human pathogenic mutation His150Tyr (p.H150Y) identified in attention-deficit hyperactivity disorder.

mutations:
Single point mutation

synonyms:
Cdh2<H150Y(1)>,
Cdh2<H150Y(1)>

earliestPublication:
Halperin D, et al. (2021) CDH2 mutation affecting N-cadherin function causes attention-deficit hyperactivity disorder in humans and mice. Nat Commun 12(1):6187

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

3 Publication categories

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