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Allele : Mlh1<em2Jcs> mutL homolog 1; endonuclease-mediated mutation 2, John C Schimenti
Primary Identifier  MGI:7276203 Allele Type  Endonuclease-mediated
Attribute String  Humanized sequence Gene  Mlh1
Strain of Origin  FVB/NJ x B6(Cg)-Tyr<c-2J>/J Is Recombinase  false
Is Wild Type  false
molecularNote  Using an sgRNA (targeting AGGCAGCTGATTCTACCAGA) and an ssODN template (AATGGGTGTGTGTTTTTGGGCAAGTATGCTGCATATACAGTTTCAATGGCTTTTCTCAAGGCAGCTGATCCTACGAGTCGGTCTGAAATCTGAAAAATCAAAAGGAGAGTTAACCAGATCACACTTG) with CRISPR/Cas9 technology, glutamic acid codon 268 (GAA) was changed to glycine (GGA) (c.803A>G, p.E268G).
  • mutations:
  • Single point mutation
  • synonyms:
  • Mlh1<E268G>,
  • Mlh1<E268G>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

2 Publication categories





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