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Allele : Msh5<em1Jzc> mutS homolog 5; endonuclease-mediated mutation 1, Zi-Jiang Chen

Primary Identifier  MGI:7260342 Allele Type  Endonuclease-mediated
Attribute String  Humanized sequence Gene  Msh5
Strain of Origin  C57BL/6 Is Recombinase  false
Is Wild Type  false
molecularNote  CRISPR/Cas9 technology generated a G to T change a position 1456, resulting in an aspartate to tyrosine substitution at residue 486 (p.D486Y) in exon 16 which is equivalent to the human p.D487Y mutation identified in two sisters with primary ovarian insufficiency.
  • mutations:
  • Single point mutation
  • synonyms:
  • Msh4<D486Y>,
  • Msh4<D486Y>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

3 Publication categories

Trail: Allele