Primary Identifier | MGI:7256567 | Allele Type | Targeted |
Attribute String | Conditional ready | Gene | Txnip |
Transmission | Germline | Strain of Origin | C57BL/6 |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Two loxP sites were introduced flanking exons 2 to 8 and another set of exons 2-8 containing a T to A change resulting in a cysteine to serine substitution at amino acid 247 (C247S) in exon 5 was incorporated after the second loxP site. In addition, a neomycin selection cassette flanked by self-deletion anchor sites was inserted upstream of the second loxP site and was removed in germ cells. |