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Allele : Mafb<tm1.1Mardu> MAF bZIP transcription factor B; targeted mutation 1.1, Martine Dunnwald
Primary Identifier  MGI:7256734 Allele Type  Targeted
Attribute String  Conditional ready, Humanized sequence Gene  Mafb
Transmission  Germline Strain of Origin  C57BL/6N
Is Recombinase  false Is Wild Type  false
molecularNote  Histidine codon 131 (CAC) in the single exon was changed to glutamine (CAG) (p.H131Q) and an FRT site flanked neomycin resistance gene cassette and a loxP site were inserted upstream and second loxP site downstream. The mutation is associated with orofacial clefts (OFCs) in humans. The neo cassette was removed through subsequent flp-mediated recombination.
  • mutations:
  • Insertion,
  • Single point mutation
  • synonyms:
  • Mafb<H131Q>,
  • Mafb<H131Q>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

4 Publication categories





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