| Primary Identifier | MGI:7257809 | Allele Type | Targeted |
| Attribute String | Not Specified | Gene | Gata1 |
| Transmission | Germline | Strain of Origin | 129S/SvEv x C57BL/6 |
| Is Recombinase | false | Is Wild Type | false |
| description | HF4 (129S/SvEv x C57BL/6) ES cells |
| molecularNote | Arginine codons 243 (CGG) and 247 (CGA) in exon 4 were changed to alanine (GCA) (p.R243A, p.R247A) and an FRT site flanked neomycin resistance gene cassette was inserted into intron 4. The neo cassette was removed through subsequent flp-mediated recombination. The mutated arginine residues are essential for binding to the Hdac1 protein but their mutation doesn't affect other binding properties. |
