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Allele : Appl2<tm1.1Smoc> adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2; targeted mutation 1.1, Shanghai Model Organisms Center

Primary Identifier	MGI:7294210	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Appl2
Transmission	Germline	Strain of Origin	Not Specified
Is Recombinase	false	Is Wild Type	false

molecularNote

Exon 5 was flanked with loxP sites. An FRT-flanked neomycin resistance cassette was inserted upstream of the loxP sites. Cre-mediated recombination removed exon 5.

mutations:
Intragenic deletion

cellLines:
Not Specified

synonyms:
Appl2 KO,
Appl2 KO

earliestPublication:
Mao L, et al. (2014) Absence of Appl2 sensitizes endotoxin shock through activation of PI3K/Akt pathway. Cell Biosci 4(1):60

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

4 Publication categories

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