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Allele : Tardbp<tm1.1Hiok> TAR DNA binding protein; targeted mutation 1.1, Hitoshi Okazawa
Primary Identifier  MGI:7282115 Allele Type  Targeted
Attribute String  Humanized sequence Gene  Tardbp
Transmission  Germline Strain of Origin  C57BL/6J
Is Recombinase  false Is Wild Type  false
molecularNote  Asparagine codon 267 (AAT) in exon 6 was changed to serine (p.N267S) and a loxP site flanked neomycin resistance gene was inserted into intron 4. The neo cassette was removed through subsequent Cre-mediated recombination. The equivalent human mutation is associated with frontotemporal lobar degeneration (FTLD).
  • mutations:
  • Nucleotide substitutions,
  • Insertion
  • synonyms:
  • TDP<N267S>,
  • TDP43-KI,
  • TDP43-KI,
  • TDP<N267S>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

5 Publication categories





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