| Primary Identifier | MGI:7282116 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Chmp2b |
| Transmission | Germline | Strain of Origin | C57BL/6J |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Glutamine codon 165 (CAA) in exon 5 was changed to a stop codon (p.Q165*) and a loxP site flanked neomycin resistance gene was inserted into intron 4. The neo cassette was removed through subsequent Cre-mediated recombination. The equivalent human mutation is associated with frontotemporal lobar degeneration (FTLD). |
