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Allele : Arhgef12<Tvrm266> Rho guanine nucleotide exchange factor 12; translational vision research model 266

Primary Identifier	MGI:7309977	Allele Type	Chemically induced (ENU)
Attribute String	Hypomorph	Gene	Arhgef12
Inheritance Mode	Dominant	Strain of Origin	B6.Cg-Crb1<rd8>/Pjn
Is Recombinase	false	Is Wild Type	false

molecularNote

This ENU-induced c.71T>A point mutation results in an early stop signal at codon 24 (p.L24*)

mutations:
Single point mutation

earliestPublication:
Weatherly SM, et al. (2022) Identification of Arhgef12 and Prkci as genetic modifiers of retinal dysplasia in the Crb1rd8 mouse model. PLoS Genet 18(6):e1009798

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

2 Publication categories

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