| Primary Identifier | MGI:7290063 | Allele Type | Endonuclease-mediated |
| Attribute String | Inserted expressed sequence | Gene | Gt(ROSA)26Sor |
| Inheritance Mode | Not Specified | Strain of Origin | FVB/N |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the liver-specific APOE promoter into the mouse Rosa26 site, which can be used to obtain liver-expressed CYP3A4 Humanized sequence model after mating with the Cyp3a13 gene and other Cyp3a family gene knockout mice. This model can be used with NM-KI-18033 mice which has gut-specific expression of human CYP3A4 to compare the contribution of intestinal versus hepatic metabolism to the biotransformation of a test article. |
