| Primary Identifier | MGI:7290143 | Allele Type | Endonuclease-mediated |
| Attribute String | Null/knockout | Gene | H2-Ab1 |
| Strain of Origin | NOD.Cg-Prkdc<scid> Il2rg<em1Smoc>/Smoc | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1 H2-AA H2-Eb1 H2-Eb2 H2-Ea-ps knockout mouse models.Also, B2m gene was knocked out. These MHC class I and II molecule-deficient mice were on the M-NSG genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins and B2m of class I. |
