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Allele : Mettl5<em1.2Snac> methyltransferase 5, N6-adenosine; endonuclease-mediated mutation 1.2, Sigrid Nachtergaele

Primary Identifier	MGI:7310451	Allele Type	Endonuclease-mediated
Attribute String	Null/knockout	Gene	Mettl5
Strain of Origin	(C57BL/6 x 129S6/SvEvTac)F1	Is Recombinase	false
Is Wild Type	false

molecularNote

CRISPR/cas9 genome editing was used to insert loxP sites on either side of exon 2 and a FRT-flanked neomycin cassette. Flp-mediated recombination removed the neo cassette. Cre-mediated recombination removed exon 2.

mutations:
Intragenic deletion

earliestPublication:
Sepich-Poore C, et al. (2022) The METTL5-TRMT112 N(6)-methyladenosine methyltransferase complex regulates mRNA translation via 18S rRNA methylation. J Biol Chem 298(3):101590

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

2 Publication categories

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