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Allele : Csn1s1<em2(CSF2)Nrba> casein alpha s1; endonuclease-mediated mutation 2, Nariman R Battulin

Primary Identifier	MGI:7312049	Allele Type	Endonuclease-mediated
Attribute String	Humanized sequence, Inserted expressed sequence, Null/knockout	Gene	Csn1s1
Strain of Origin	129S2/SvPasCrl	Is Recombinase	false
Is Wild Type	false

description	DGES1 ES cells (129S2/SvPasCrl) were used.
molecularNote	CRISPR/Cas9 technology replaced the entire Csf2 open reading frame (exons 2-33, 13.7 Kb) with the human CSF2 open reading frame.

mutations:
Insertion,
Intragenic deletion

synonyms:
REP-GM,
REP-GM

earliestPublication:
Smirnov AV, et al. (2022) Evaluation of the alpha-casein (CSN1S1) locus as a potential target for a site-specific transgene integration. Sci Rep 12(1):7983

1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

2 Publication categories

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