| First Author | Schuster C | Year | 2022 |
| Journal | Front Immunol | Volume | 13 |
| Pages | 906499 | PubMed ID | 35720357 |
| Mgi Jnum | J:326437 | Mgi Id | MGI:7293533 |
| Doi | 10.3389/fimmu.2022.906499 | Citation | Schuster C, et al. (2022) CD5 Controls Gut Immunity by Shaping the Cytokine Profile of Intestinal T Cells. Front Immunol 13:906499 |
| abstractText | CD5 is constitutively expressed on all T cells and is a negative regulator of lymphocyte function. However, the full extent of CD5 function in immunity remains unclear. CD5 deficiency impacts thymic selection and extra-thymic regulatory T cell generation, yet CD5 knockout was reported to cause no immune pathology. Here we show that CD5 is a key modulator of gut immunity. We generated mice with inducible CD5 knockdown (KD) in the autoimmune-prone nonobese diabetic (NOD) background. CD5 deficiency caused T cell-dependent wasting disease driven by chronic gut immune dysregulation. CD5 inhibition also exacerbated acute experimental colitis. Mechanistically, loss of CD5 increased phospho-Stat3 levels, leading to elevated IL-17A secretion. Our data reveal a new facet of CD5 function in shaping the T cell cytokine profile. |
