| Primary Identifier | MGI:7316614 | Allele Type | Endonuclease-mediated |
| Attribute String | Hypomorph | Gene | Dot1l |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | CRISPR/cas9 mediated recombination introduced an AA to GC mutation in exon 9 creating an asparagine 241 to alanine substitution. This mutation lies within the histone catalytic domain and eliminates H3K79 methylation activity. |
