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Allele : Rr44608<em1Ddu> regulatory region 44608; endonuclease-mediated mutation 1, Denis Duboule

Primary Identifier	MGI:7327108	Allele Type	Endonuclease-mediated
Attribute String	Modified regulatory region	Gene	Rr44608
Strain of Origin	C57BL/6 x CBA	Is Recombinase	false
Is Wild Type	false

molecularNote

Using an sgRNA (targeting ACAGCGCCTCCTCCTGGACA) with CRISPR/Cas9 technology, a 21 bp deletion (GAGGAGGCGCTGTAGGACAAG) was created in this Hoxd CTCF binding site region.

mutations:
Intergenic deletion

synonyms:
Del(CBS1),
deltaCB1,
HoxD<Del(CBS1)->,
HoxD<Del(CBS1)->,
deltaCB1,
Del(CBS1)

earliestPublication:
Amandio AR, et al. (2021) Sequential in cis mutagenesis in vivo reveals various functions for CTCF sites at the mouse HoxD cluster. Genes Dev 35(21-22):1490-1509

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

2 Publication categories

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