Primary Identifier | MGI:7333121 | Allele Type | Endonuclease-mediated |
Attribute String | No functional change | Gene | Tg(DMD*)Idel52Lumc |
Strain of Origin | STOCK Tg(DMD)72Thoen Dmd<mdx>/Lumc | Is Recombinase | false |
Is Wild Type | false |
molecularNote | TALEN-targeting of exon 52 produced a partial deletion of the 5' end of exon 52 and a 2.3 kb inversion including intron 51 and the last 93 bp of exon 52 in both copies of the transgene. Loss of exon 52 results in the loss of DMD protein expression. |