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Allele : Misfadt<em1Psv> mitochondrial sheath formation associated divergent transcript; endonuclease-mediated mutation 1, Petr Svoboda

Primary Identifier	MGI:7330166	Allele Type	Endonuclease-mediated
Attribute String	Null/knockout	Gene	Misfadt
Strain of Origin	C57BL/6J	Is Recombinase	false
Is Wild Type	false

molecularNote

CRISPR/Cas9 technology generated a 1678 bp deletion including the promoter, exon 1 and exon 2 (7:46974556-46976233). qPCR and in situ hybridization confirmed absence of transcript in oocytes.

mutations:
Intragenic deletion

synonyms:
Sirena1<->,
Sirena1<->

earliestPublication:
Ganesh S, et al. (2020) The most abundant maternal lncRNA Sirena1 acts post-transcriptionally and impacts mitochondrial distribution. Nucleic Acids Res 48(6):3211-3227

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

3 Publication categories

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