| Primary Identifier | MGI:7484418 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Gba1 |
| Transmission | Germline | Strain of Origin | C57BL/6JSmoc |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exons 5-7 (and intervening introns) were replaced with the human equivalents where exon 6 has a p.Phe252Ile (or p.F213I) mutation (NM_000157.4:c.754T>A). The FRT site flanked neomycin resistance gene cassette that was inserted was removed through subsequent Flp-mediated recombination. The human mutation is associated with Gaucher disease (GD). |
