| Primary Identifier | MGI:7387060 | Allele Type | Endonuclease-mediated |
| Attribute String | Humanized sequence | Gene | Rab7 |
| Inheritance Mode | Dominant | Strain of Origin | C57BL/6J |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A single G to A substitution in exon 5 at codon 162 resulting in a V162M substitution at the end of the sequence KEAINV, consistent with a human disease allele, was introduced via CRISPR/cas9 along with a silent G to A base substitution at Q164, 8 base pairs from the functional G to A substitution, to prevent guide reassociation with the modified allele. |
