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Allele : Rr149356<tm1.1Fwa> regulatory region 149356; targeted mutation 1.1, Frederick W Alt

Primary Identifier	MGI:7386932	Allele Type	Targeted
Attribute String	Modified regulatory region	Gene	Rr149356
Transmission	Germline	Strain of Origin	129S/SvEv-Gpi1<c>
Is Recombinase	false	Is Wild Type	false

molecularNote

A HpaI-NcoI restriction fragment containing the core Ebeta Tcrb enhancer was replaced with a loxP site flanked neomycin resistance gene cassette. The neo cassette was removed through subsequent cre-mediated recombination.

mutations:
Insertion,
Intergenic deletion

cellLines:
Not Specified

synonyms:
EbetaKOdelta,
EbetaKOdelta

earliestPublication:
Bories JC, et al. (1996) Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility. Proc Natl Acad Sci U S A 93(15):7871-6

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

3 Publication categories

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